FOR LABORATORY RESEARCH PURPOSES ONLY. This compound has not received FDA approval. All information shown is drawn from published laboratory research for educational purposes
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Epithalon is a synthetic tetrapeptide studied in laboratory research for its interaction with telomerase-related and cellular-maintenance signaling pathways. It is supplied by Peppy Peptides for laboratory research use only.
Epithalon, also referred to as Epitalon, is a synthetic tetrapeptide modeled on epithalamin, a naturally occurring peptide preparation derived from the pineal gland. It consists of a short four-amino-acid sequence that researchers study for its relationship to telomerase-related signaling and cellular-maintenance pathways.
Because of its structural link to pineal-gland physiology, laboratory research has also examined how Epithalon interacts with pinealocyte-signaling models and circadian-rhythm-related pathways. Epithalon is a fully synthetic, sequence-defined peptide rather than the naturally derived epithalamin preparation, so researchers use it as a standardized reference compound in pineal-peptide research.
Epithalon is commonly referenced in laboratory literature on telomerase-related signaling, where researchers study its interaction with telomerase-activity assays in cell-culture models. It is also examined in research on cellular-maintenance pathways, including in-vitro models of chromosomal-stability signaling.
Some published research has explored the interaction of Epithalon with circadian-rhythm and pinealocyte-signaling pathways, given its structural relationship to epithalamin. Researchers studying peptide-based models of cellular-senescence signaling have used Epithalon as a reference compound in structure-activity studies of short tetrapeptide sequences. Epithalon is intended solely for in-vitro and animal-model laboratory research.
Epithalon is studied in laboratory research for its interaction with telomerase-related and cellular-maintenance signaling pathways.
Epithalamin is a naturally derived peptide preparation from the pineal gland. Epithalon is a fully synthetic, sequence-defined tetrapeptide modeled on it, which makes it usable as a standardized reference compound.
Published laboratory research on Epithalon is indexed on PubMed.
For research use only. Not for human consumption. Not evaluated by the FDA. Not intended to diagnose, treat, cure, or prevent any disease. This compound has not received FDA approval. All information shown is drawn from clinical studies for educational purposes.
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Lab-verified quality
Each lot is analysed by Bioviridian before release. Below is the Certificate of Analysis for the most recent lot, as issued by the laboratory.
Overall purity
99.8%
RP-HPLC (214 nm)
View the signed COA (PDF)Check this certificate at bioviridians.com/coa-search.html with code COA7686.
Test results
5 of 5 conformHPLC retention time 2.021 min · Signed: Shane Straight, M.S., Principal Chemist, Bioviridian Inc.
Every lot keeps its own signed certificate. Lots are listed newest first.
Lot EPITH072026-MG
99.8%
Overall purity
Tested July 13, 2026
Open COAEarlier lots will appear here as new Certificates of Analysis are published.
Compound details
Molecular profile
Storage requirements
Supplied in lyophilized (freeze-dried) form; store at −20°C for long-term stability.
Once reconstituted, store refrigerated at 2–8°C and use within 4–6 weeks; avoid repeated freeze-thaw cycles.
Published literature
3 peer-reviewed publications indexed on PubMed. Listed for reference only; inclusion does not imply any use, effect or endorsement.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE · 2003
Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells
Khavinson VKh, Bondarev IE, Butyugov AA Bulletin of experimental biology and medicine. 2003;135(6):590-2. doi:10.1023/a:1025493705728
Examined telomerase catalytic subunit expression, telomerase activity and telomere length in cultured human fetal fibroblasts exposed to the Epithalon tetrapeptide.
MOLECULES (BASEL, SWITZERLAND) · 2020
Khavinson V, Diomede F, Mironova E, et al. Molecules (Basel, Switzerland). 2020;25(3):609. doi:10.3390/molecules25030609
Examined neurogenic differentiation marker gene expression and protein synthesis in human gingival mesenchymal stem cells exposed to AEDG peptide, with modelling of peptide-histone interactions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES · 2025
Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties
Araj SK, Brzezik J, Mądra-Gackowska K, et al. International journal of molecular sciences. 2025;26(6):2691. doi:10.3390/ijms26062691
Reviewed published in vitro, animal and mechanistic studies on the pineal tetrapeptide Epitalon (Ala-Glu-Asp-Gly), including telomerase-, antioxidant- and gene-expression-related findings.
