FOR LABORATORY RESEARCH PURPOSES ONLY. This compound has not received FDA approval. All information shown is drawn from published laboratory research for educational purposes
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GHK-Cu is a naturally occurring copper-binding tripeptide composed of glycine, histidine and lysine, supplied by Peppy Peptides for laboratory research use only. GHK-Cu is used by investigators as a model compound for studying high-affinity copper-ion coordination chemistry.
GHK-Cu is a small tripeptide that forms a stable complex with Cu(II) ions. Its histidine residue coordinates copper with high affinity, and that property is the reason it is widely used as a model compound in copper-biology research.
In laboratory settings, GHK-Cu is studied for its interaction with extracellular-matrix signaling pathways, including collagen and glycosaminoglycan synthesis pathways. It is also studied for its interaction with antioxidant enzyme-signaling cascades linked to copper-dependent enzymatic activity.
GHK-Cu is referenced in laboratory models examining copper-ion transport, extracellular-matrix signaling and oxidative-stress-response pathways. In connective-tissue biology, investigators have used GHK-Cu as a reference compound for examining how copper-peptide complexes interact with matrix metalloproteinase and cytokine-signaling networks in cell-culture and animal-model systems.
GHK-Cu is also examined in research on antioxidant enzyme signaling, including superoxide dismutase pathway activity, within inflammatory-signaling research models. These applications are limited to controlled laboratory research, and findings from this literature do not indicate any approved application in humans or animals.
GHK-Cu is a copper-binding tripeptide studied in laboratory research for its interaction with extracellular-matrix and antioxidant enzyme-signaling pathways.
The histidine residue in GHK-Cu coordinates Cu(II) ions with high affinity and forms a stable complex. This makes GHK-Cu a well-defined reference compound for studying copper-peptide coordination chemistry.
Published laboratory research on GHK-Cu is indexed on PubMed.
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For research use only. Not for human consumption. Not evaluated by the FDA. Not intended to diagnose, treat, cure, or prevent any disease. This compound has not received FDA approval. All information shown is drawn from clinical studies for educational purposes.
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Compound details
Molecular profile
Storage requirements
Store the lyophilized compound at −20°C for long-term stability.
Once reconstituted, refrigerate at 2–8°C and use within 4–6 weeks; protect from light and repeated freeze-thaw cycles.
Published literature
1 peer-reviewed publication indexed on PubMed. Listed for reference only; inclusion does not imply any use, effect or endorsement.
FEBS LETT · 1988
Maquart FX, Pickart L, Laurent M, et al. FEBS Lett. 1988;238(2):343-346. doi:10.1016/0014-5793(88)80509-x
Measured collagen synthesis in cultured human fibroblasts exposed to the GHK-Cu complex across a range of concentrations.
