FOR LABORATORY RESEARCH PURPOSES ONLY. This compound has not received FDA approval. All information shown is drawn from published laboratory research for educational purposes
$125.00
Lost, stolen, or damaged? We replace it, on us.
Pick your speed at checkout.
Before you continue
This site sells research products exclusively to qualified researchers and laboratories for in vitro and laboratory use. Please confirm before continuing.
Thymosin Alpha-1 is a naturally occurring polypeptide fragment, supplied as 10mg of lyophilized powder for laboratory research use only. Also known as Thymosin Alpha, TA1 or Tα1, it is studied in laboratory research for its interaction with immune-cell signaling pathways.
Thymosin Alpha-1 is a polypeptide fragment derived from Thymosin Fraction 5, a thymic-tissue extract first characterised in early thymic-peptide research. It belongs to the thymosin family, a class of small polypeptides originally isolated from thymic tissue. Thymosin Alpha-1 is defined by a specific 28-amino-acid sequence, which distinguishes it from the other fragments isolated from Thymosin Fraction 5 and has made it a frequently cited compound in thymic-peptide literature.
Published research has explored how Thymosin Alpha-1 interacts with immune-cell signaling pathways, including those involved in T-cell maturation and the regulation of cytokine signaling.
Thymosin Alpha-1 is commonly studied by researchers examining immune-cell signaling, including in vitro assays of T-cell differentiation and cytokine regulation. Research on Toll-like receptor pathway activity also uses Thymosin Alpha-1 to examine its interaction with innate immune-signaling networks.
Because it originates from thymic tissue, Thymosin Alpha-1 is often a subject of research comparing natural thymic-peptide fragments with synthetic analogues. Comparative protocols sometimes examine it alongside other thymic-peptide fragments and immune-signaling compounds to separate pathway-specific activity within combined in vitro models.
Thymosin Alpha-1 is a fragment derived from Thymosin Fraction 5, an extract of thymic tissue. It is one of several peptides isolated from that fraction.
It is also referred to as Thymosin Alpha, TA1 and Tα1.
Published laboratory research on Thymosin Alpha-1 is indexed on PubMed.
Related Research Compounds: LL-37 - 10mg • Browse all Immunity research compounds
For research use only. Not for human consumption. Not evaluated by the FDA. Not intended to diagnose, treat, cure, or prevent any disease. This compound has not received FDA approval. All information shown is drawn from clinical studies for educational purposes.
Researcher favourites
Price range: $125.00 through $175.00
Price range: $150.00 through $650.00
Price range: $125.00 through $700.00
$150.00
$175.00
Lab-verified quality
Each lot is analysed by Bioviridian before release. Below is the Certificate of Analysis for the most recent lot, as issued by the laboratory.
Overall purity
99.8%
RP-HPLC (214 nm)
View the signed COA (PDF)Check this certificate at bioviridians.com/coa-search.html with code COA7703.
Test results
5 of 5 conformHPLC retention time 9.302 min · Signed: Shane Straight, M.S., Principal Chemist, Bioviridian Inc.
Every lot keeps its own signed certificate. Lots are listed newest first.
Lot TA1072026-MG
99.8%
Overall purity
Tested July 13, 2026
Open COAEarlier lots will appear here as new Certificates of Analysis are published.
Compound details
Molecular profile
Storage requirements
Store lyophilized compound at −20°C for long-term stability. Avoid repeated freeze-thaw cycles, protect from prolonged light exposure.
Refrigerate at 2–8°C after reconstitution and use within 4–6 weeks.
Published literature
3 peer-reviewed publications indexed on PubMed. Listed for reference only; inclusion does not imply any use, effect or endorsement.
PROC NATL ACAD SCI U S A · 1977
Thymosin alpha1: isolation and sequence analysis of an immunologically active thymic polypeptide
Goldstein AL, Low TL, McAdoo M, et al. Proc Natl Acad Sci U S A. 1977;74(2):725-729. doi:10.1073/pnas.74.2.725
Reported the isolation of thymosin alpha-1 from calf thymus fraction 5 and determination of its 28-amino-acid sequence.
BLOOD · 2004
Romani L, Bistoni F, Gaziano R, et al. Blood. 2004;103(11):4232-4239. doi:10.1182/blood-2003-11-4036
Examined the effect of thymosin alpha-1 on murine and human dendritic cells in vitro and in a mouse Aspergillus model, identifying involvement of toll-like receptor (TLR9/MyD88) signaling.
FRONT MED (LAUSANNE) · 2024
Phenotypic drug discovery: a case for thymosin alpha-1
Garaci E, Paci M, Matteucci C, et al. Front Med (Lausanne). 2024;11:1388959. doi:10.3389/fmed.2024.1388959
Reviewed the history, structure and proposed molecular mechanisms of thymosin alpha-1 as an example of phenotype-based drug discovery.
