FOR LABORATORY RESEARCH PURPOSES ONLY. This compound has not received FDA approval. All information shown is drawn from published laboratory research for educational purposes
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TB-500 is a synthetic peptide fragment of Thymosin Beta-4, supplied by Peppy Peptides for laboratory research use only. TB-500 is used in controlled studies of cellular-migration and cytoskeletal signaling.
Thymosin Beta-4 is a naturally occurring 43-amino-acid protein found in most human and animal cells. TB-500 is a synthetic peptide derived from it and belongs to the broader class of actin-binding peptides.
Actin is a structural protein involved in cell movement and cytoskeletal organization. TB-500 is studied for its binding to actin and its interaction with cellular-migration and tissue-repair signaling pathways. Researchers also use TB-500 as a reference compound when studying the signaling behavior of full-length Thymosin Beta-4 in cell-based and animal-model systems.
TB-500 is referenced in laboratory literature on cellular-migration signaling, where researchers study its interaction with actin-binding pathways in cell-based models. It is also examined in research on tissue-repair signaling, including in vitro models of wound-margin cell migration and angiogenesis-related pathways.
Published research has also examined TB-500's interaction with cytoskeletal-organization pathways relevant to studies of cell shape and motility. In structure-activity research, TB-500 serves as a reference compound when comparing fragment activity with full-length Thymosin Beta-4 in laboratory assays.
TB-500 is studied for its interaction with actin-binding, cellular-migration and tissue-repair signaling pathways in cell-based and animal-model systems.
TB-500 is a synthetic peptide derived from Thymosin Beta-4, a naturally occurring actin-binding protein. Researchers use it to compare fragment activity with the full-length protein.
Published laboratory research on Thymosin Beta-4 is indexed on PubMed.
For research use only. Not for human consumption. Not evaluated by the FDA. Not intended to diagnose, treat, cure, or prevent any disease. This compound has not received FDA approval. All information shown is drawn from clinical studies for educational purposes.
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Lab-verified quality
Each lot is analysed by Bioviridian before release. Below is the Certificate of Analysis for the most recent lot, as issued by the laboratory.
Overall purity
99.8%
RP-HPLC (214 nm)
View the signed COA (PDF)Check this certificate at bioviridians.com/coa-search.html with code COA7701.
Test results
5 of 5 conformHPLC retention time 9.114 min · Signed: Shane Straight, M.S., Principal Chemist, Bioviridian Inc.
Every lot keeps its own signed certificate. Lots are listed newest first.
Lot TB500072026-MG
99.8%
Overall purity
Tested July 13, 2026
Open COAEarlier lots will appear here as new Certificates of Analysis are published.
Compound details
Molecular profile
Storage requirements
Supplied lyophilized; store at −20°C for long-term stability; avoid repeated freeze-thaw cycles
Refrigerate at 2–8°C after reconstitution; use within 4–6 weeks
Published literature
1 peer-reviewed publication indexed on PubMed. Listed for reference only; inclusion does not imply any use, effect or endorsement.
THE JOURNAL OF BIOLOGICAL CHEMISTRY · 1991
Thymosin beta 4 and Fx, an actin-sequestering peptide, are indistinguishable
Safer D, Elzinga M, Nachmias VT The Journal of biological chemistry. 1991;266(7):4029-32.
Sequenced the platelet actin-sequestering peptide Fx, identified it as thymosin beta-4, and characterized its 1:1 binding to G-actin and inhibition of actin polymerization.
